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Daily Upsider - Wednesday, July 30th, 2025
Wednesday, July 30th, 2025
Good Morning! đ
Thereâs Still Time to Call That Old Friend
Today is International Day of Friendshipâa quiet but meaningful reminder that connection is a lifeline, not a luxury. Whether itâs a decades-old bond or a neighbor youâve just begun to trust, friendships are the glue holding us steady in uncertain times.
So go aheadâwrite that message, make that call, or send that photo from 1987. You never know who needs it more: them, or you. đ
Todayâs Upside
Earth Science
A Squid Imposter

Reconstruction of Nektognathus, swimming in the Cambrian Sea. - Bob Nicholls
A long-standing mystery about ancient squid-like creatures has finally been solved. Researchers from the University of Bristol, working with fossil finds from North Greenland, have uncovered the true origins of nectocarididsâenigmatic animals that lived over 500 million years ago. With heads and tentacle-like appendages, these creatures bore a striking resemblance to early cephalopods, the group that includes squids, cuttlefish, and octopuses. For years, scientists believed thatâs exactly what they were. But new evidence reveals a surprising twist: nectocaridids werenât cephalopods at allâthey were early relatives of arrow worms.
Dr. Jakob Vinther of the University of Bristol had long been skeptical of the cephalopod classification. A 15-year-old study based on Burgess Shale fossils had placed nectocaridids within the cephalopod lineage, but the anatomical details never quite fit. Hoping to clarify their place in the evolutionary tree, paleontologists launched expeditions to Sirius Passet, a renowned Cambrian fossil site in North Greenland known for its exceptional soft tissue preservation. There, they discovered 25 well-preserved nectocaridid fossilsâsome containing traces of nervous system structures. âWe discovered our nectocaridids preserve parts of their nervous system as paired mineralised structures, and that was a giveaway as to where these animals sit in the tree of life,â said Vinther.
The clinching evidence came from a preserved ventral ganglionâa nerve mass unique to arrow worms. âWe now had a smoking gun to resolve the nectocaridid controversy,â said Dr. Tae-Yoon Park of the Korean Polar Institute. âNectocaridids share a number of features with some of the other fossils that also belong to the arrow worm stem lineage.â Though they appeared squid-like, many of these traits were simple adaptations for swimmingâsimilar to how marine reptiles and whales evolved fish-like forms. Further comparisons with fossil arrow worms such as Timorebestia and Amiskwia confirmed the link. The team named the species Nektognathus evasmithae, in honor of human rights advocate Professor Eva Smith. âSo, the ancestors of arrow worms were really complex predators, just like the squids that only evolved about 400 million years later,â Vinther said. Far from passive drifters, these ancient swimmers were equipped with camera-like eyes, long antennae, and stealthy hunting skillsââa smart and stealthy fighter,â as Vinther put it.
Health Science
Regrowing Teeth?

Freepik
The human body contains 206 bonesâflexible, resilient structures made of calcium, minerals, and collagen that enable movement and can even regenerate after a break. Teeth, however, donât share that regenerative power. Despite being the hardest substance in the body due to their enamel coating, once damaged, teeth cannot repair or regrow. That may soon change, thanks to a groundbreaking development in Japan: scientists have created an experimental drug designed to regrow human teeth, with clinical trials already underway.
Led by Dr. Katsu Takahashi, head of dentistry at Kitano Hospital in Osaka, the research builds on earlier discoveries involving a protein called USAG-1, which suppresses tooth development. In 2021, researchers from Kyoto University used a monoclonal antibody to block USAG-1 and its interaction with bone morphogenetic proteins (BMPs), successfully triggering new tooth growth in animals. âWe knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,â Takahashi said at the time. Encouraged by promising results in ferretsâwhose dental development mirrors that of humansâhis team is now testing the therapy in people.
The current trial, which began in September 2024, involves 30 men between the ages of 30 and 64 who are missing at least one tooth. The drug is administered intravenously and will be studied over 11 months. No side effects were seen in animal models. If successful, the next step is a pediatric trial for children aged 2 to 7 with congenital tooth loss. The long-term vision is ambitious: a tooth-regrowing drug available to the public by 2030. âWhile there has been no treatment to date providing a permanent cure, we feel that peopleâs expectations for tooth growth are high,â said Takahashi. Eventually, he hopes the therapy could restore teeth for anyone who has lost themâushering in a new era of regenerative dentistry.
Lifestyle
Dogsâ New Beginnings

Senior dogs, including Maya (center) â Submitted by The Grey Muzzle Organization
Last week, the Grey Muzzle Organizationâthe nationâs largest nonprofit dedicated solely to senior dogsâannounced a record-breaking $1.57 million in grants to 119 animal welfare groups across the U.S. Itâs the largest funding round in the organizationâs history, supporting efforts to give older dogs the love, care, and homes they deserve. âIf 50 is the new 30 for humans, why not for our older best friends?â said Grey Muzzleâs director. âSenior dogs have so much life to live, and love to give, yet theyâre often the last to be adopted and the first at risk when shelters run out of space,â added Denise Fleck.

Credit: Golden Bark â submitted by The Grey Muzzle
The grants, distributed to organizations in 33 states, will fund medical and dental care, adoption initiatives, foster and hospice programs, and other vital services that help senior dogs stay in their homesâor find new ones. Many older dogs arrive at shelters with untreated health issues. But now, thanks to this funding, dogs like Mayaâwho spent a decade confined in a breeding pen and faced euthanasia due to shelter overcrowdingâhave a second chance. A sanctuary in Arizona took her in with help from Grey Muzzleâs grant. âI am so excited that her story is getting out there to help raise awareness about senior dogs,â said her new owner, Caroline Mirtich.
Since 2008, Grey Muzzle has awarded $7.3 million in grants to senior dog programs across the country. Among this yearâs recipients are The Golden Bark Foundation, a volunteer-run Utah rescue focused on fostering aging dogs. Their grant will go toward dental care, their top medical expense, since 80% of their dogs suffer from serious dental disease. Another grantee, Czarâs Promise in Wisconsinânamed after a Great Pyreneesâsupports families managing pet cancer; their funds will cover chemotherapy and radiation for dogs aged 7 and older. With this new wave of support, more senior dogs will get the care they need and the homes they deserve in their final years. A full list of 2025â26 grantees is available on the Grey Muzzle website.
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Midweek check-in: Have you unclenched your jaw today? Breathed from your belly? Drunk water that wasnât coffee?
Today, weâre putting you back on your own to-do list. Your body holds stress like a suitcase it never got to unpackâbut small habits can lighten the load.
đĄ Wellness Tip of the Week:
Try the â5-5-5 Resetâ â
5 deep belly breaths
5 stretches (neck rolls, shoulder shrugs, wrist circles, etc.)
5 minutes with no screens, just stillness or a view
Doesnât seem like much? Your nervous system will thank you.
Youâre not behind, youâre just healing. Keep going, gently.
Mind Stretchers
âïž
"Iâm never shy of stormy skies,
I open wide but have no eyes.
Though I may turn with wind's wild dance,
In rain or shine, I take my stance.
Held above, yet not too proudâ
What am I, beneath the cloud?"
Yesterdayâs Answers to the Mind Stretchers:
I have two blades but never bite, I open wide, then close real tight. I love to split but never fightâ Snipping through your work just right. What am I? â a pair of scissors! âïž Sandra Gottschalk got this correct first! đ
Be the first to send us the correct answer for todayâs mind stretcher for a shout-out with the answer tomorrow. Just send us the answer and your name to [email protected] or reply to email.
From the Community
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