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Daily Upsider - Friday, June 27th, 2025
Friday, June 27th, 2025
Good Morning đ
Itâs Fridayâfinally!
The week may have had its twists, turns, and triple-shot coffees, but you made it. Todayâs a gentle nudge to pause, smile, and soak up the little wins. In this edition, weâve gathered the good stuffâstories to uplift, inspire, and carry you warmly into the weekend.
Todayâs Upside
Health Science
Memory Boosting Herbs

Freepik
Rosemary has long been tied to memory, so itâs no surprise that scientists are studying its compoundsâalong with those from sageâas potential tools against Alzheimerâs disease. Researchers at Scripps Research have focused on carnosic acid, a natural antioxidant and anti-inflammatory compound found in both herbs. While effective in theory, carnosic acid is too unstable for drug use. To solve this, scientists developed a more stable version called diAcCA, which converts into carnosic acid in the gut and is then absorbed into the bloodstream.
In a new study published in Antioxidants, diAcCA improved memory and increased synapse density in Alzheimerâs mouse models. Since synaptic loss closely correlates with dementia, the findings are encouraging. The compound also reduced Alzheimerâs biomarkersâamyloid-β and phosphorylated tau proteinsâand lowered brain inflammation. Notably, the compound only activates in inflamed tissue, potentially reducing side effects. âBy combating inflammation and oxidative stress with this diAcCA compound, we actually increased the number of synapses in the brain,â said senior author Professor Stuart Lipton, MD, PhD. âWe also took down other misfolded or aggregated proteins such as phosphorylated-tau and amyloid-β.â

Alzheimerâs-like mouse brain (left) compared to more intense green color (right) showing neuron synapses that underlie learning and memory after treatment â Credit Scripps Research
Backed by the National Institutes of Health, the study showed that mice treated with diAcCA for three months performed better on spatial learning tests, and their brain tissue showed more synaptic connections and fewer harmful protein deposits. âWe did multiple different tests of memory, and they were all improved with the drug,â Lipton said. âAnd it didnât just slow down the decline; it improved virtually back to normal.â Mice tolerated the treatment well, even showing reduced gastrointestinal inflammation during digestion. With its strong safety profileâcarnosic acid is already FDA-designated as GRASâLipton believes diAcCA could enter clinical trials soon and potentially be used alongside existing Alzheimerâs drugs or even in treating other inflammation-related diseases like type 2 diabetes and Parkinsonâs.
History
A Giant Archaeological Puzzle

Specialist Han Li reconstructing wall plaster from fresco â Credit: Museum of London Archaeology (MOLA)
Excavations at a construction site in London have uncovered one of the largest collections of painted Roman wall plaster ever found in the city. The fragments once decorated a high-status Roman building in Southwark, which was demolished before 200 CE. Among the finds are rare pieces, including ancient Greek graffiti and a painterâs partial signatureâexceptional discoveries that shed new light on Roman art in Britain. The site, already known for mosaics and a rare mausoleum, confirms the areaâs importance in Roman-era London.
The fragments were discovered by archaeologists from the Museum of London Archaeology (MOLA), scattered in a large pit where they were dumped during the buildingâs original demolitionânot due to modern construction. MOLAâs Han Li, a senior building material specialist, spent three months carefully sorting and reconstructing the plaster. âThis has been a once in a lifetime moment, so I felt a mix of excitement and nervousness when I started to lay the plaster out,â Li said. âMany of the fragments were very delicate and pieces from different walls had been jumbled together⌠like assembling the worldâs most difficult jigsaw puzzle.â
The restored designs feature rare yellow panels with black borders, adorned with birds, fruit, lyres, and floral motifsâelements meant to reflect the wealth and taste of the original owner. Yellow panels were uncommon in Britain, previously seen only at elite sites like Fishbourne Roman Palace. The fragments also mimic luxury materials like Egyptian red porphyry and African marble, echoing styles from across the Roman Empire, including Germany, France, and Pompeii. One plaster piece bears the Latin word FECITââhas made thisââwithin a Roman tabula ansata, marking the first known painterâs signature of its kind in Britain. Another fragment shows a nearly complete Greek alphabet, likely etched by a skilled writer for practical use. As Han Li continues piecing together the ornate designs, MOLA plans to publish and possibly display the findings, preserving artwork not seen since Roman times.
Lifestyle
Built From the Wild
Lately, Iâve been feeling a stronger pull toward the outdoorsâmaybe itâs the chaos of the world, or maybe itâs just a craving for something real. Camping videos, off-grid living, building with your hands⌠all that grounding, elemental stuff.
Thatâs how I came across Madison Clysdale, a creator whose videos are as raw and quietly magnetic as the wilderness she films in. Her latest shows her building a bushcraft-style log cabin from scratch on her 15-acre property in British Columbiaâno power tools, no shortcuts, just basic gear and what she gathers from the land. Thereâs no flashy editing or sponsor shoutoutsâjust the sound of trees falling, logs stacking, and moss being pressed into place for insulation. Her dogâs always nearby (and honestly deserves his own channel), keeping her company through the stillness, the storms, and the occasional visit from a bear or raven.
What I love about Madisonâs work is that it never tries too hard. It doesnât need to. Itâs quiet, patient, and real. Watching her build feels like stepping into a different pace of lifeâwhere every action has weight and every moment holds its own kind of meaning. It made me pause and wonder: Could you see yourself living like this? Off-grid, no Wi-Fi, just the forest, a fire, and something you made with your own hands?
Let me knowâIâm genuinely curious who else has been daydreaming about disappearing into the woods (even if just for a weekend).
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For this weekâs Funny Friday, weâre heading underwaterâwhere marine life proves itâs not always graceful. Caught on camera in all their clumsy, curious glory, these ocean dwellers remind us that even nature has its off days. A good laugh, no snorkel required. đ
@funny_car_525 Marine Animals core.#marineanimals #animal #animals #animalsoftiktok #animallover #core #cuteanimals #funnyanimals #foryour #fyp #fypăˇ
Mind Stretchers
âď¸
I have a head but wear no hat,
I strike with force, imagine that.
I can build or I can break,
In careful hands or a madman's quake.
What am I?
Yesterdayâs Mind Stretchers:
I do not speak, yet stories I tell,
Of warriors, lovers, and oceans that swell.
I vanish by day, but at night I appear,
A million tiny lights, cold and clear.
What am I? â stars! ⨠Debbie Ettinger got this correct first!
Be the first to send us the correct answer for todayâs mind stretcher for a shout-out with the answer tomorrow. Just send us the answer and your name to [email protected]or reply to the email.
From the Community
If you have any uplifting stories and experience you might want to share, send those over to [email protected] for the chance to be featured.
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